Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

University of Copenhagen

Status: Enrolling

Conditions: Obesity

Treatments: Other: GLP-1 + saline; Other: Saline + saline; Other: Neurotensin + saline; Other: GLP-1 + Neurotensin

Study type: Interventional

Funder types: Other

Identifiers

NCT04186026

514-0386/19-3000

Details and patient eligibility

About

Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

Full description

Neurotensin (NT), a gut hormone and neuropeptide, and GLP-1, as well a gut hormone, increases in circulation after bariatric surgery in rodents and humans and inhibit food intake in mice.

Studies in rodents have shown that a GLP-1 receptor agonist and long acting neurotensin inhibit food intake.

This study investigates whether the synergistic anorexic effects of neurotensin and GLP-1 agonism suggested by animal studies can be translated.

Enrollment: 35 estimated patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Informed consent
• Above 18 years of age
• Normal hemoglobin concentration
• 28<BMI<40 kg/m2

Exclusion criteria

• Diabetes mellitus
• Truncal vagotomy
• Resection of intestine (apart from appendectomy)
• Tobaccos use
• Nephropathy (serum-creatinin>130 micromolar or/and albuminuria)
• Liver disease (Alanine transaminase or/and aspartate transaminase>2 times normal range.)
• Treatment with medication that cannot be paused in 12 hours
• Allergy towards latex or plastic
• Bleeding disorder

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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35 participants in 4 patient groups

Saline+Saline

Other group

Treatment:

Other: Saline + saline

Neurotensin+Saline

Other group

Treatment:

Other: Neurotensin + saline

GLP-1+Saline

Other group

Treatment:

Other: GLP-1 + saline

Neurotensin + GLP-1

Other group

Treatment:

Other: GLP-1 + Neurotensin