co2 Gap and co2/o2 Ratio in Liver Transplant Patients (co2gap)

Kasr El Aini Hospital

Status: Unknown

Conditions: Liver Transplantation

Treatments: Diagnostic Test: Fluid challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT03374579

N-60-2017

Details and patient eligibility

About

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Full description

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.

Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients post liver transplantation
• serum lactate >2mmol/L

Exclusion criteria

• age less than 18 years
• patients with fulminant liver failure.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

CO2 gap

Experimental group

Description:

The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.

Treatment:

Diagnostic Test: Fluid challenge