CO2 Laser and Open Surgery for T1N0 Glottic SCC With Anterior Commissure Involved

Xuekui Liu

Status: Enrolling

Conditions: Squamous Cell Carcinoma of Glottis

Treatments: Procedure: Open Surgery; Procedure: CO2 Laser surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT02303457

2014012

Details and patient eligibility

About

Open surgery and CO2 laser surgery are both established treatment modalities for T1N0 glottic carcinoma. It is controversial for T1N0 glottic carcinoma with anterior commissure involved.

Enrollment: 402 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• T1N0 SCC of glottic carcinoma with anterior commissure involve
• No nodal metastasis and distant metastasis
• All patients must have CT/MR and electronic laryngoscope test before surgery and after surgery
• Expected lifetime>1 year
• Patients and families agreed to participate in the test and sign the informed consent
• Without cognitive impairment.

Exclusion criteria

• With severe cardiac insufficiency Liver and kidney function is not complete systemic infection patients
• Patients with pregnancy and lactation
• Have surgery contraindications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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402 participants in 2 patient groups

CO2 laser surgery

Experimental group

Description:

CO2 Laser surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved. All patients, under general anesthesia, underwent endoscopic excision of the lesion using a carbon dioxide (CO2) laser (Sharplan 100) coupled with a microscope (Zeiss) set to an output power of between 5 and 12 W in superpulse mode. The lesion's resection was accomplished in a radical fashion, with a free margin of 2 mm. For lesions which involved the anterior commissure, the excision plane always uncovered the cartilage.

Treatment:

Procedure: CO2 Laser surgery

Open surgery

Other group

Description:

Open Surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved. open surgery :Frontolateral Vertical Partial Laryngectomy or laryngofissure with cordectomy was accomplished in a radical fashion, with a free margin of 2 mm.

Treatment:

Procedure: Open Surgery