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Coagulation Disturbances in COVID-19 Septic Patients

C

Cantonal Hospital Zenica

Status

Completed

Conditions

Coagulation Disorder
COVID 19 Associated Coagulopathy
Septic Shock
Sepsis

Treatments

Diagnostic Test: CAC in septic patients

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Objective of this study was to determine the relationship between CAC and septic condition in COVID-19 critically ill patients. Data including age, sex, comorbidities, quick Sequential Organ Failure Assessment (qSOFA) score, vasopressors requirement, laboratory findings: platelets, neutrophils, lymphocytes, procalcitonin (PCT), C-reactive protein (CRP), fibrinogen, D-dimer, sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC) score were recorded on the day of admission and on the day of starting of invasive mechanical ventilation. Primary outcome was to establish CAC with sepsis; secondary outcome measure was incidence of CAC in sepsis and septic shock in COVID-19 critically ill patients.

Enrollment

100 patients

Sex

All

Ages

18 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • all adult critically ill patients tested positive for reverse transcriptase polymerase chain reaction (RT-PCR) of nasopharyngeal swabs to coronavirus 2 (SARS-CoV-2)
  • patienets admitted to the ICU and presented with acute hypoxemic respirator failure

Exclusion criteria

  • patients younger than 18,
  • immunodeficient patients,
  • patients with a history of malignancies,
  • patients who developed septic state before admission,
  • patients with a history of previous coagulopathy, liver and platelet disease.

Trial design

100 participants in 2 patient groups

Sepsis
Treatment:
Diagnostic Test: CAC in septic patients
Septic shock
Treatment:
Diagnostic Test: CAC in septic patients

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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