Coagulation Disturbances in COVID-19 Septic Patients

Cantonal Hospital Zenica

Status: Completed

Conditions: Coagulation Disorder; COVID 19 Associated Coagulopathy; Septic Shock; Sepsis

Treatments: Diagnostic Test: CAC in septic patients

Study type: Observational

Funder types: Other

Identifiers

NCT05496816

CAC

Details and patient eligibility

About

Objective of this study was to determine the relationship between CAC and septic condition in COVID-19 critically ill patients. Data including age, sex, comorbidities, quick Sequential Organ Failure Assessment (qSOFA) score, vasopressors requirement, laboratory findings: platelets, neutrophils, lymphocytes, procalcitonin (PCT), C-reactive protein (CRP), fibrinogen, D-dimer, sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC) score were recorded on the day of admission and on the day of starting of invasive mechanical ventilation. Primary outcome was to establish CAC with sepsis; secondary outcome measure was incidence of CAC in sepsis and septic shock in COVID-19 critically ill patients.

Enrollment: 100 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all adult critically ill patients tested positive for reverse transcriptase polymerase chain reaction (RT-PCR) of nasopharyngeal swabs to coronavirus 2 (SARS-CoV-2)
• patienets admitted to the ICU and presented with acute hypoxemic respirator failure

Exclusion criteria

• patients younger than 18,
• immunodeficient patients,
• patients with a history of malignancies,
• patients who developed septic state before admission,
• patients with a history of previous coagulopathy, liver and platelet disease.

Trial design

100 participants in 2 patient groups

Sepsis

Treatment:

Diagnostic Test: CAC in septic patients

Septic shock

Treatment:

Diagnostic Test: CAC in septic patients