Coagulation Profile of Patients Undergoing CRS(Cytoreductive Surgery) and Hyperthermic Intraperitoneal Chemotherapy

Rajiv Gandhi Cancer Institute & Research Center, India

Status: Completed

Conditions: Haematological Abnormality

Treatments: Other: thromboelastography

Study type: Observational

Funder types: Other

Identifiers

NCT03137745

RGCI ID:395/AN/FSP-08

Details and patient eligibility

About

To study the changes in coagulation profile in patients undergoing cytoreductive surgery and Hyperthermic intraperitoneal chemotherapy. The objective of the study is to determine the utility of thromboelastography in comparison to standard coagulation tests in assessing the coagulopathy in patients undergoing CRS with HIPEC.

Full description

This is a prospective observational study conducted in 60 patients undergoing CRS with HIPEC in RGCIRC from march 2015- march2016 after taking permission from the institutional review board and informed written consent from the patients.

Arterial blood samples were collected before and after HIPEC and on first and second postoperative day for PT,APTT INR,TEG and ABG. Statistical analysis was done using chi square test and unpaired t- test for categorical and continuous variables. Pearson's correlation coefficient was calculated for analysing the correlation between the variables .P - value <0.05 was considered statistically significant.

Enrollment: 60 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1&2
• Undergoing CRS with HIPEC

Exclusion criteria

• extremities of age
• patients with coagulopathy
• patients on anticoagulant preoperatively sever organ dysfunctions

Trial design

60 participants in 1 patient group

all patients undergoing CRS with HIPEC

Description:

thromboelastography was done in 60 patients undergoing CRS with HIPEC in RGCI FROM MARCH2015- MARCH 2016

Treatment:

Other: thromboelastography