Cocoa Flavanol and Coronary Vasomotion Vascular Function in Patients With Coronary Artery Disease

University of Zurich (UZH)

Status

Completed

Conditions

Stable Coronary Heart Disease

Treatments

Dietary Supplement: flavanol-rich drink vs flavanol-free drink

Study type

Interventional

Funder types

Other

Identifiers

NCT02520466

EK2012-0201

Details and patient eligibility

About

The aim of the present study is to investigate whether the ingestion of a cocoa flavanol-containing drink compared to a flavanol-free drink, improves coronary vasomotion and platelet function in patients with overt coronary artery disease acutely (after 2 hours)

Enrollment

37 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with coronary artery disease undergoing elective coronary angiography with or without the need of coronary intervention

Age 20 - 80
Written obtained informed consent

Exclusion criteria

Acute ST-elevation myocardial infarction
Acute non-ST-elevation myocardial infarction (enzyme positive)
Ventricular tachy-arrythmias or AV-Block >I°
Renal insufficiency (GFR MDRD < 30ml/min) or liver disease (ALT or AST >150 IU)
Pregnancy
Known allergy to compounds of cocoa product
Known allergy to contrast media
Known allergy to nuts
Intolerance to coffein and theobromin
Acute infectious disease
Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
Participation in another study within the last month
Concomitant vitamin supplements and herbal remedies, as well as fruit and tea extracts
No study visits ± 1 week before Eastern, Christmas and New Year holyday (altered eating habits)
Extreme eating habits (as assessed by a questionnaire)
Alcohol or drug abuse
Lactose intolerance