Cocoa Polyphenols and Postprandial Metabolism in Type 2 Diabetes

Arpita Basu

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: Cocoa polyphenols

Study type: Interventional

Funder types: Other

Identifiers

NCT01886989

HE-12-52

Details and patient eligibility

About

This study aims to investigate the postprandial effects of cocoa supplementation in glucose and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes. The investigators aim to test the hypothesis that cocoa will lower high-fat mixed meal breakfast-induced postprandial rise of glucose, lipids and markers of atherosclerosis in patients with diabetes. Randomized cross-over controlled trial, in which participants will be assigned to the placebo or cocoa group with breakfast meal. Patients with type 2 diabetes(n=25) will qualify for the study. The participants will be asked to consume 2 cups cocoa or placebo beverage on 2 separate postprandial study days. Both groups will receive high-fat mixed meal breakfast on each day. Blood draws and blood pressure (including HDI) measurements will be conducted at fasting, 30 min, 1,2, 4 & 6 hours postprandial each day for 2 days.

Enrollment: 18 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of type 2diabetes

Exclusion criteria

• on insulin therapy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 2 patient groups, including a placebo group

Cocoa

Experimental group

Description:

Cocoa polyphenols (960mg)

Treatment:

Dietary Supplement: Cocoa polyphenols

Placebo

Placebo Comparator group

Description:

Placebo powder (109mg polyphenols) in water

Treatment:

Dietary Supplement: Cocoa polyphenols