Coeliac Plexus Neurolysis Versus Splanchnic Nerve Neurolysis

The University of Hong Kong (HKU)

Status: Enrolling

Conditions: Cancer Pain

Treatments: Other: Splanchnic nerve neurolysis; Other: Coeliac plexus neurolysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05541211

UW22-536

Details and patient eligibility

About

Pain is prevalent among patients with gastrointestinal cancers. Standard procedures such as coeliac plexus neurolysis (CPN) is effective in reducing pain, opioid requirement and related side effects for pancreatic cancer cases. Meanwhile, splanchnic nerve neurolysis (SNN) as an alternative to CPN is more effective for cancer pain relief.

Although previous studies investigating the role of CPN/SNN mainly focus on pancreatic cancer cases, their efficacy on non-pancreatic abdominal cancer pain may not be accurately determined.

Full description

Pain is prevalent among patients with gastrointestinal cancers. There is abundant evidence that coeliac plexus neurolysis (CPN) is effective in reducing pain, opioid requirement and related side effects for pancreatic cancer cases while the evidence for other upper abdominal cancer pain is less robust but emerging. Meanwhile, there is an increasing interest in utilising splanchnic nerve neurolysis (SNN) as an alternative to CPN for cancer pain relief.

Although previous studies investigating the role of CPN/SNN involved heterogenous types of intra-abdominal malignancies, majority of cases were pancreatic cancer. Therefore, their efficacy on non-pancreatic abdominal cancer pain may not be accurately determined.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age>=18
• Diagnosis of unresectable intra-abdominal cancer
• Visceral pain attributable to the cancer with NRS >= 4
• Able to understand instructions, give consent, complete questionnaires

Exclusion criteria

• Primary pancreatic cancer or metastatic disease involving pancreas
• Gross celiac axis distortion identified on imaging
• Acute abdomen condition eg. Intraabdominal sepsis, tumor rupture
• Other non-cancer causes attributable to the pain
• Gross ascites
• Previous coeliac plexus or splanchnic nerve neurolysis
• Contraindications to neurolytic procedures eg. Bleeding tendency; local or systemic infections; allergic to local anesthetics, contrast or alcohol; intestinal obstruction; anatomical distortion along needle trajectory
• Patients believed to be inappropriate for study by investigators

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Coeliac plexus neurolysis (CPN)

Active Comparator group

Description:

Coeliac plexus neurolysis (CPN) will be performed bilaterally. Neurolytic solution will be injected around the coeliac plexus (a network of nerves located in the abdomen).

Treatment:

Other: Coeliac plexus neurolysis

Splanchnic nerve neurolysis (SNN)

Experimental group

Description:

Splanchnic nerve neurolysis (SNN) will be performed bilaterally. Neurolytic solution will be injected around the splanchnic nerves (a nerve located at thoracic trunk).

Treatment:

Other: Splanchnic nerve neurolysis