Coenzyme Q10 in Older Athletes Treated With Statin Medications

Richard Deichmann, MD

Status and phase: Completed; Phase 4

Conditions: Myalgia; Side Effects of Statins; Muscle Weakness

Treatments: Drug: Coenzyme q 10; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01026311

09-076

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of coenzyme Q10 administration in improving mitochondrial function as measured by anaerobic threshold in older athletes on a stable dose of statin medication.

Enrollment: 20 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients ≥ 50 years of age, male or female.

• Patients on a stable dose of statin medication for at least 3 months prior to enrollment in the study

• Self-Described Athletes with any of the following characteristics:

  • Participation in a competitive athletic event within the past year or currently training for a competitive athletic event within the 6 months following enrollment
  • Regular exercise activity of at least 45 minutes duration 5 times per week

Exclusion criteria

• Use of coenzyme Q10 during the preceding two months.
• CPK level at baseline greater than two times the upper limits of normal
• LDL level at baseline greater than 160 for those without a cardiovascular risk or cardiovascular risk equivalent
• LDL level at baseline greater than 130 for those with a cardiovascular risk or cardiovascular risk equivalent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Treatment:

Drug: placebo

Coenzyme Q10

Active Comparator group

Description:

200mg of coenzyme Q10

Treatment:

Drug: Coenzyme q 10