Coffee for Optimal Metabolite Profile

Chalmers University of Technology

Status: Completed

Conditions: Healthy

Treatments: Other: Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT05757154

ChalmersUA

Details and patient eligibility

About

The aim of this project is to evaluate metabolite profile after consumption of three types of coffee differing in type of bean, degree of roasting and preparation method. Metabolite profiles will be evaluated after a) a single dose b) 3-day consumption. The study will be carried out as a three-way cross-over design with three different types of coffee. Wash-out periods where participants consume their habitual diet are implemented between all intervention periods. The first day of intervention (single dose) includes postprandial measurements during 13 hours.

Enrollment: 12 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females and males
• 18 to 80 years of age
• Body mass index (BMI) 18.5-30.0 kg/m2
• Fasting glucose ≤ 6.1 mmol/l
• Low density lipoprotein (LDL) cholesterol ≤ 5.30 mmol/l
• Triglycerides ≤ 2.60 mmol/l
• Signed informed consent

Exclusion criteria

• Food allergies or intolerances preventing consumption of any products included in the study.
• Unable to sufficiently understand written and spoken Swedish to provide written consent and understand information and instructions from the study personnel.
• Pregnant, lactating or planning a pregnancy during the study period.
• Antibiotic use for the last 3 months.
• Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study.
• History of stomach or gastrointestinal conditions (Inflammatory bowel disease, Chron's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.)
• Previous major gastrointestinal surgery
• Have type I diabetes
• Thyroid disorder

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 3 patient groups

Coffee A

Experimental group

Description:

Coffee type A. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method.

Treatment:

Other: Diet

Coffee B

Experimental group

Description:

Coffee type B. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method.

Treatment:

Other: Diet

Coffee C

Experimental group

Description:

Coffe type C. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method.

Treatment:

Other: Diet