Coffee Polyphenols Antioxidants

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Other: maltodextrin enriched with caffeine; Other: coffee polyphenols mixed with placebo; Other: coffee

Study type: Interventional

Funder types: Industry

Identifiers

NCT01832662

10.07.MET

Details and patient eligibility

About

Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood. In addition, chlorogenic acids are known to be antioxidants in the cup, but reliable evidence remains to be observed in vivo. The objective of this trial is to understand if regular (10d) coffee intake may be beneficial on biomarkers of oxidative damage measured in urine and plasma. A secondary objective is to understand if polyphenols isolated from coffee may be as beneficial as the whole beverage in reducing oxidative stress compared to placebo

Full description

This is an interventional study with a crossover randomized placebo-controlled double-blind design to assess the effect of regular consumption of coffee on oxidative stress compared to placebo.

Enrollment: 60 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20 - 70 years, male and female
• healthy
• BMI 19 - 29 kg/m2
• Coffee drinkers with an average consumption of 1-3 cups per day
• having given informed consent

Exclusion criteria

• Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer- Have had a gastrointestinal surgery, except appendicectomy
• Difficulty to swallow
• Have a regular consumption of medication
• Have taken antibiotic therapy within the last 6 months
• Alcohol consumption > 2 units a day
• Smokers (more than 5 cigarettes per day)
• Have given blood within the last 3 weeks
• Volunteers who cannot be expected to comply with treatment
• Currently participating or having participated in another clinical trial during the last 3 weeks

Trial design

60 participants in 3 patient groups, including a placebo group

Coffee

Experimental group

Description:

4 cups/day of 2.5g of coffee each

Treatment:

Other: maltodextrin enriched with caffeine

Other: coffee polyphenols mixed with placebo

coffee polyphenols mixed with placebo

Active Comparator group

Description:

4 cups/day of 2.5g of product each

Treatment:

Other: maltodextrin enriched with caffeine

Other: coffee

maltodextrin enriched with caffeine

Placebo Comparator group

Description:

4 cups/day of 2.5g of product each

Treatment:

Other: coffee polyphenols mixed with placebo

Other: coffee