Cognition and Gut Microbiome Associated Study of Shanghai People With Acute Ischemic Stroke

Tongji University

Status: Unknown

Conditions: Gastrointestinal Microbiome

Treatments: Dietary Supplement: Probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT03812445

cognitionstroke

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of ischemic stroke patients.

Full description

This study aims to detect the impact of probiotics administration during the process of ischemic stroke treatment and recovery phase. The day of admission and 3months after stroke data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the stroke patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with acute ischemic stroke on the basis of World Health Organization diagnostic criteria1.

the time from paroxysm to admission ≤2weeks.

Exclusion criteria

• Imaging diagnoses hemorrhagic stroke Severe depression Severe disturbance of hearing vision and reading Illiteracy Have recognitive disorder before stroke (recorded in medical records) Treated with antibiotics probiotics or prebiotics in1month before admission

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

No Intervention

No Intervention group

Description:

the patients in this arm will not receive probiotics.

Experimental

Experimental group

Description:

the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus for 3 months.

Treatment:

Dietary Supplement: Probiotics