Cognition and NeuroImaging in neuroDegenerative Disorders (CogNID)

NHS Trust

Status: Enrolling

Conditions: Dementia (Diagnosis)

Treatments: Diagnostic Test: Cognitive assessments

Study type: Observational

Funder types: Other

Identifiers

NCT03861884

18NS001

Details and patient eligibility

About

This prospective study aims:

1. to compare cognitive performance in different clinical groups of participants with mild cognitive impairment (MCI) or mild dementia [Alzheimer's Disease (AD), Vascular Cognitive Impairment (VCI) and Fronto-temporal Dementia (FTD)] to determine whether scores reveal differential profiles between the groups,
2. to demonstrate differences in imaging markers between different dementia syndromes and healthy volunteers using ultra high-field MRI at 7T.

Full description

The imaging arm of the study include:

1. to demonstrate differences in brain iron levels between different dementia syndromes and healthy volunteers using ultra high-field MRI, quantitative susceptibility mapping (QSM) at 7T.
2. to demonstrate variations in the resting oxygen usage as an important biomarker to discriminate between different dementia syndromes.
3. to demonstrate cerebral blood flow changes in the brain, particularly in the hippocampus region, and its correlation with different dementia syndromes using Arterial Spin Labelling MRI technique.
4. to demonstrate increased blood brain barrier leakage in the brain, particularly in the hippocampus region, and its correlation with Alzheimer's Disease (AD) and Vascular Cognitive Impairment (VCI) using a new dynamic contrast-enhanced MRI (DCE-MRI) technique.

Enrollment: 125 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Ability to give informed consent.
2. Either pathological, genetic or imaging biomarker evidence to suggest Fronto-temporal Lobar Degeneration, Alzheimer's Disease or Vascular Cognitive Impairment, or defined clinical diagnoses.

Exclusion criteria

1. Lack of mental capacity to consent to study involvement.
2. Not speaking English before age 5 years.
3. Learning disability.
4. MRI contraindications

Trial design

125 participants in 3 patient groups

Cognitive assessments

Description:

Neurocognitive assessments, Birmingham Cognitive Screen

MRI at 3T

Description:

Brain Imaging: MRI at 3T

Treatment:

Diagnostic Test: Cognitive assessments

MRI at 7T

Description:

Brain imaging: Ultrahigh Field MRI at 7T

Treatment:

Diagnostic Test: Cognitive assessments