Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy (CogAMS)

University Hospital of Bordeaux

Status

Completed

Conditions

Multiple System Atrophy

Treatments

Other: MRI

Other: Clinical evaluation

Other: neuropsychological battery test

Other: Actigraphy

Study type

Observational

Funder types

Other

Identifiers

NCT02185677

CHUBX 2013/07

Details and patient eligibility

About

The main objective of the study is to compare the score to the Behavioral Dysexecutive Syndrome Inventory (BDSI) between Parkinsonian Multiple system Atrophy MSA-P patients and cerebellar Multiple System Atrophy (MSA-C) patients matched on disease duration, age (± 7 years) and sex .

Full description

Multiple system atrophy (MSA) is a rare neurodegenerative disorder which is characterized by a variable combination of parkinsonism, cerebellar dysfunction, autonomic failure, and additional signs. According to the consensus criteria for the diagnosis of MSA, the presence of dementia is considered an exclusion criteria. However, several studies have reported cognitive impairment in patients with MSA, dominated by a dysexecutive syndrome. Some studies have compared the cognitive profile of MSA-P patients and MSA-C but any have studied the behavioral dysexecutive syndrome in this population. In 2010, the GREFFEX has established criteria for dysexecutive syndrome and described two distinct parts: the dysexecutive syndrome and cognitive behavioral dysexecutive syndrome. Our clinical impression is that according to the type of MSA, the dysexecutive syndrome seems to be different : the MSA-P patients seem to have a cognitive dysexecutive syndrome and the MSA-C patients a behavioral dysexecutive syndrome.

We want to compare the BDSI score between MSA-P patients and MSA-C patients matched on disease duration, age and sex The specific involvement of the cerebellum in behavioral disorders could explain the behavioral differences experienced by clinicians caring for these patients but never demonstrated. The presence of these disorders could have an impact on the relationship between the patient and the caregiver. In addition, few studies have correlated with cognitive imagery data. Therefore, the exact areas involved in cognitive and behavioral MSApatients remain poorly understood.

Enrollment

40 patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients suffering from "probable" MSA according to clinical consensus criteria (Gilman et al, 2008),
Age >30
Written informed consent
Patient covered by the national health system
The presence of an informant
Blood negative dosage of the hormone béta-hCG for the women old enough to procreate

Exclusion criteria

UMSARS IV score > 4 points
Pregnant woman (blood positive dosage of the hormone béta-hCG) or breast feeding
Patient under tutelage
Patient unable to give consent
Against indication to perform an MRI