Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome (WILL-COPE)

University Hospital Center (CHU)

Status: Unknown

Conditions: Anxiety; Williams Syndrome

Treatments: Behavioral: Cognitive and Behavioral Therapy

Study type: Observational

Funder types: Other

Identifiers

NCT03827525

RECHMPL18_0375

Details and patient eligibility

About

Patients with Williams-Beuren syndrome are eight times more likely to suffer from anxiety compared to the general population. Few therapeutic solutions are proposed to these patients. The objective of this research is to validate a cognitive and behavioral therapy anxiety protocol for patients with this syndrome.

Full description

Most studies agree that anxiety disorders are more frequent in people with intellectual disabilities that in the general population. Williams syndrome (WS) is a rare disease, associated with an anxiety rate 8 times higher than in the general population. The therapeutic solutions proposed in this population remain limited, in particular concerning approaches without the use of medication. The objective of the study is to evaluate the effectiveness of a program of Cognitive and Behavioral Therapies (CBT) in Williams Syndrome (WS). For this, an ABA-type protocol will be used. It consists of evaluating the effectiveness of an interventional program longitudinally, using a single case type study. Adults patients with WS and suffering from anxiety will be recruited. They will be enrolled in a program consisting in nine sessions of a psychotherapy program targeting anxiety. There will be a pretherapy visit (day 0), nine sessions of psychotherapy (month 0 to month 5) and a visit 3 month after the end of the therapy (at month 8) : the visit of the end of the research (V10). The expected results will be to validate a psychotherapeutic program for patients with WS suffering of anxiety. This program might be extended to other patients with intellectual disability.

Enrollment: 5 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Williams Syndrome
• Complaint about anxiety
• 18 years old and more
• Score of 7 or more at the CELF-4 (it is a scale assessing the language)
• informed consent signed

Exclusion criteria

• Scoring less than 7 at the CELF-4
• Hearing impairment
• Visual impairment

Trial design

5 participants in 1 patient group

Cognitive and Behavioral Therapy

Description:

There is no group, the study will be based on single case method. The sudy concerns 5 patients with a Williams Syndrome

Treatment:

Behavioral: Cognitive and Behavioral Therapy