Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or Maintenance

Northumbria University

Status: Completed

Conditions: Caffeine Withdrawal; Cognitive Function; Cerebral Haemodynamics; Mood

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Caffeine and Placebo; Dietary Supplement: Placebo and Caffeine; Dietary Supplement: Caffeine

Study type: Interventional

Funder types: Other

Identifiers

NCT01376882

24G4

Details and patient eligibility

About

The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood. Cerebral blood flow effects will also be assessed in a subset of participants. The role of caffeine abstinence/maintenance in the acute effects of caffeine will also be explored.

Full description

The current randomised, placebo-controlled, double-blind, parallel groups study aims to explore the behavioural effects of 2-weeks caffeine abstinence as well as establishing the role of abstinence in the effects of caffeine administration by administering caffeine or placebo to those in a state of chronic and acute abstinence. This research also aims to explore, in a subset of participants, the cerebral blood flow effects of caffeine abstinence and caffeine administration using Near Infrared Spectroscopy (NIRS). Cerebral blood flow will be measured both at rest and during performance of cognitive tasks.

Enrollment: 110 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male/Female
• 18 - 40 years
• Healthy
• Consume ≥ 150 mg caffeine daily
• No herbal supplements/prescription medications (excl. contraceptive pill)
• Non smoker
• Native English speaker

Exclusion criteria

• Diagnosis of any significant medical condition or disorder
• Any known allergy or hypersensitivity to food.
• BMI >29.9 or <18.5
• Blood pressure >139/89

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

110 participants in 4 patient groups

Acute withdrawal

Experimental group

Description:

Chronic intervention 100 mg caffeine capsules 3 times per day for 14 days. Acute intervention of placebo capsule on day 15.

Treatment:

Dietary Supplement: Caffeine and Placebo

Acute caffeine-independent of withdrawal

Experimental group

Description:

Chronic intervention of placebo capsules 3 times per day for 14 days. Acute intervention of 100 mg caffeine capsule on day 15.

Treatment:

Dietary Supplement: Placebo and Caffeine

Chronic abstinence

Experimental group

Description:

Chronic intervention of placebo capsules 3 times per day for 14 days. Acute intervention of placebo capsule on day 15.

Treatment:

Dietary Supplement: Placebo

Acute caffeine-in state of withdrawal

Experimental group

Description:

Chronic intervention of 100 mg caffeine capsule 3 times per day for 14 days. Acute intervention of 100 mg caffeine capsule on day 15.

Treatment:

Dietary Supplement: Caffeine