Cognitive and Emotional Impairment After Stroke

Sykehuset Asker og Baerum

Status: Completed

Conditions: Cognitive Impairment; Stroke; Vascular Dementia

Treatments: Other: Multifactorial vascular-risk-factor-intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT00506818

1.2006.2076(REK)

16307(NSD)

Details and patient eligibility

About

Cognitive and emotional symptoms are often seen in the acute phase of a stroke. The prevalence of such symptoms later and the mechanisms explaining the symptoms are not fully known. The causes of poststroke dementia are likely to be multifactorial (Cerebrovascular Diseases 2006). The investigators want to include all patients with first ever stroke without significant cognitive decline prior to the stroke (IQCODE cut-off 3,7) and follow them up for one year. At baseline we will make stroke classifications, measure neurological deficits according to NIHSS, evaluate cognitive and emotional function and make registrations of vascular risk factors, including precerebral color duplex scan with measurement of IMT in CCA. The investigators will then randomize the patients into multifactorial vascular-risk-factor-intervention in the hospital or care as usual in the primary health care. 8-12 months after stroke onset, survivors will undergo new examinations to evaluate neurological, cognitive and emotional functions, as well as MRI and SPECT.

Enrollment: 250 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• First ever stroke or TIA
• No cognitive decline (IQCODE < 3,7)
• Survived the acute stroke
• Expected to live at least for one year after stroke

Exclusion criteria

• Cognitive decline

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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250 participants in 1 patient group

2

Active Comparator group

Description:

Intensive risk factor intervention

Treatment:

Other: Multifactorial vascular-risk-factor-intervention