Cognitive and Mood Effects of Docosahexaenoic Acid (DHA)-Rich and Eicosapentaenoic Acid (EPA)-Rich Fish Oil in Healthy Young Adults

Northumbria University

Status: Completed

Conditions: Cognitive Function; Mood

Treatments: Dietary Supplement: Placebo; Dietary Supplement: n-3 PUFAs

Study type: Interventional

Funder types: Other

Identifiers

NCT01075919

16N1

Details and patient eligibility

About

To date, only a small handful of studies have assessed the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cognitive function in healthy adults. The results from these studies are mixed, and have differed greatly in terms of methodology as regards sample size, treatment formulation and duration of the intervention. In order to address these issues, the present study aims to assess the effects of two different formulations of fish oil in parallel, and at doses consistent with the current recommended daily intake of oily fish, across a range of cognitive domains. The aim of the present investigation is therefore to specifically evaluate the effects of 12 weeks supplementation of DHA-rich fish oil and EPA-rich fish oil dietary supplements on cognitive function in healthy young adults maintaining a regular diet containing oily fish not more than once a week. Self-report mood assessments will form the secondary part of this investigation.

Enrollment: 159 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male/Female
• 18-35 years
• Healthy
• No herbal supplements/prescription medications (excl. contraceptive pill)
• Non smoker
• Native English speaker

Exclusion criteria

• Consumes ≥ 1 portion oily fish/week
• takes omega-3 supplement
• Food allergies to treatment ingredients

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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159 participants in 3 patient groups, including a placebo group

DHA-rich fish oil

Active Comparator group

Description:

1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA

Treatment:

Dietary Supplement: n-3 PUFAs

Dietary Supplement: n-3 PUFAs

EPA-rich fish oil

Active Comparator group

Description:

1 g EPA-rich fish oil containing 300 mg EPA + 200 mg DHA

Treatment:

Dietary Supplement: n-3 PUFAs

Dietary Supplement: n-3 PUFAs

Placebo

Placebo Comparator group

Description:

1 g Olive oil

Treatment:

Dietary Supplement: Placebo