Cognitive Behavior Therapy Among Patients With Major Depressive Disorder-Multiple Episodes.

Government College University Faisalabad

Status: Not yet enrolling

Conditions: Patients With Major Depressive Disorder

Treatments: Behavioral: Cognitive Behavior Therapy; Drug: treatment as usual (TAU) (Control Group)

Study type: Interventional

Funder types: Other

Identifiers

NCT07300527

GCUF_PsychThesisTrial

Details and patient eligibility

About

The main purpose of this study to teach the patients how to manage their depression, generalized Anxiety symptoms, mental health seeking attitude, motivation and attitude toward changing health, to improve the quality of life, and meta memory and meta cognitive functioning after using Adapted CBT. Enhance emotional regulation by helping patients identify and modify maladaptive emotional responses, thereby reducing emotional reactivity and promoting healthier coping strategies. Strengthen relapse prevention skills by equipping patients with long-term cognitive and behavioral techniques to recognize early warning signs and apply learned strategies proactively to prevent future episodes. This research would be helpful for patients etc.

Full description

In this experimental study, 120 patients will be screened for eligibility from various government and private hospitals. Participants meeting the DSM-5-TR criteria for Major Depressive Disorder (multiple episodes) will be considered. Eighty eligible participants will be randomly assigned to the experimental group (n = 40) and control group (n = 40). Participants aged 18-50 years will be included. Following approval from the university and formal permissions from hospitals and patients, all ethical guidelines will be strictly observed. Eligible participants will be selected based on the inclusion criteria. The CBT group will receive two sessions per week, gradually reduced over time, with each session lasting 45-60 minutes. Pre- and post-assessments will be conducted using standardized measures to evaluate changes in depression severity and related psychological variables.

Expected outcome: The intervention is expected to significantly reduce symptoms of depression and anxiety among participants. Improvements are anticipated in help-seeking attitudes, motivation toward health behavior change, and overall quality of life. CBT is also expected to enhance meta-memory and meta-cognitive functioning. These outcomes will support the effectiveness of CBT in treating patients with recurrent MDD.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 50 weeks old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age range: 18-50 years No physical, psychiatric, or psychological conditions. patients who meet multiple Episodes. who meet DSM 5 TR Major Depressive Disorder Criteria. patients who meet moderate severity at patient health questionnaire scale .

Exclusion criteria

• age range: below 18 and above 50 years. presence of any physical, psychiatric, or psychological conditions. who do not meet DSM 5 TR Major Depressive Disorder Criteria. range at patient health questionnaire scale is mild , minimal or severe or moderately severe.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

1st Arm (1- Experimental)

Experimental group

Description:

Patients will receive cognitive behavioral Therapy

Treatment:

Drug: treatment as usual (TAU) (Control Group)

Behavioral: Cognitive Behavior Therapy

2nd Arm (Waitlist Control Condition)

Active Comparator group

Description:

This group will receive treatment as usual

Treatment:

Drug: treatment as usual (TAU) (Control Group)