Cognitive Behavioral Therapy for Treatment of Adult Attention Deficit Hyperactivity Disorder

Mass General Brigham

Status: Completed

Conditions: Attention Deficit Disorder With Hyperactivity

Treatments: Other: Relaxation techniques and education about ADHD; Behavioral: Cognitive behavioral therapy (CBT)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00118911

2003-P-000523 (Other Identifier)

R01MH069812 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study will determine the efficacy of cognitive behavioral therapy in treating adults with attention deficit hyperactivity disorder.

Full description

Attention deficit hyperactivity disorder (ADHD), previously believed to be a disorder of childhood, affects as many as 5 percent of adults. Adults with ADHD are at high risk for academic and occupational underachievement, relationship difficulties, and reduced quality of life. This study will determine whether cognitive behavioral therapy (CBT) is more effective than ADHD education and relaxation techniques in treating adults with ADHD.

Participants will be randomly assigned to receive 12 to 15 weekly sessions of either CBT or training in which they will learn relaxation techniques and receive detailed information about ADHD. Questionnaires will be used to assess participants' ADHD symptoms at study entry and at study completion.

The study is being conducted at Massachusetts General Hospital in Boston and requires 5 assessment visits and 12 weekly therapy visits. Participants must be able to travel to Boston on a weekly basis in order to participate in the study.

Study hypothesis: CBT is a more efficacious treatment for adult ADHD than education and relaxation techniques.

Enrollment: 86 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of adult ADHD of at least mild clinical severity (CGI score of 3 or greater)
• Stable on medications for adult ADHD for at least 2 months
• Between 18 and 65 years old
• Be able to give informed consent and comply with study procedures

Exclusion criteria

• Moderate to severe major depression, clinically significant panic disorder (CGI for depression or panic greater than 4), bipolar disorder, organic mental disorders, psychotic disorders, or pervasive developmental disorders
• Active suicidality (HAM-D suicidality item rated 3 or 4)
• Current substance abuse or dependence
• IQ less than 90
• Suicide risk
• Prior participation in cognitive behavioral therapy for ADHD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

86 participants in 2 patient groups

Cognitive-Behavioral Therapy

Experimental group

Description:

Participants will receive cognitive-behavioral therapy following our protocol.

Treatment:

Behavioral: Cognitive behavioral therapy (CBT)

Relaxation with Educational Support

Active Comparator group

Description:

Applied relaxation plus educational support (RES).

Treatment:

Other: Relaxation techniques and education about ADHD