Cognitive Behavioral Therapy Plus Drug Treatment for Obsessive Compulsive Disorder (Aug1)

New York State Psychiatric Institute

Status: Completed

Conditions: Obsessive-Compulsive Disorder

Treatments: Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy); Behavioral: Stress Management Therapy (Cognitive Behavior Therapy)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00045903

R01MH045436-01 (U.S. NIH Grant/Contract)

IRB #4734R

DSIR AT-CT

Details and patient eligibility

About

This study will evaluate the effectiveness of two cognitive behavioral therapies (CBTs) in treating obsessive compulsive disorder (OCD) in patients who are taking medication but still have residual symptoms.

Full description

Participants remain on their current OCD medication and are randomly assigned to receive one of two CBTs: exposure and ritual prevention or stress management therapy. Exposure and ritual prevention involves imaginal and in-vivo exposure and requires that participants refrain from ritualizing. Stress management involves relaxation, assertiveness training, and structured problem-solving. Therapy occurs twice per week for 2 months. Participants are assessed verbally by an independent evaluator and are asked to complete self-rating forms. Patients who respond are followed for up to 1 additional year. Participants continue to take the same medication and the same monthly therapy for the first 6 months of follow-up. During the second 6 months of follow-up, participants discontinue therapy but continue taking the same medication.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00389493

Enrollment: 136 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obsessive-Compulsive Disorder (OCD) diagnosis
• Currently taking a serotonin reuptake inhibitor (SRI, i.e. clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline, or citalopram) for OCD

Exclusion criteria

• Medical or psychiatric conditions that would make participation in the study hazardous
• Intensive cognitive-behavioral therapy while on an adequate dose and duration of an SRI for OCD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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136 participants in 2 patient groups

Exposure and Ritual Prevention

Experimental group

Description:

Exposure and Ritual Prevention Therapy

Treatment:

Behavioral: Exposure and Ritual Prevention (Cognitive Behavioral Therapy)

Stress Management

Active Comparator group

Description:

Stress Management Therapy

Treatment:

Behavioral: Stress Management Therapy (Cognitive Behavior Therapy)