Cognitive Changes in Mild Cognitive Impairment

Fujian Medical University (FJMU)

Status: Enrolling

Conditions: Healthy Controls Without Orthostatic Hypotension

Treatments: Other: observational study

Study type: Observational

Funder types: Other

Identifiers

NCT05821400

Cohort-MCI

Details and patient eligibility

About

Background: In recent years, the changes of cognitive function in mild cognitive impairment have attracted attention.

Methods/design: We will follow up at 3. The primary outcome will be the measurement of cognitive function using neuropsychological assessment scales such as MOCA, MMSE, etc... Minor variables will be included plasma biomarkers (Aβ, Tau, GFAP, etc.), multimodal brain electrophysiology (P300, VP300, heart rate variability, etc.), and neuroimaging indicators (NODDI).

Enrollment: 200 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically diagnosed mild cognitive impairment

Exclusion criteria

• Patients with orthostatic hypotension
• Patients with other neurological disorders.
• Pregnant or lactating women.

Trial design

200 participants in 1 patient group

Healthy controls without orthostatic hypotension

Treatment:

Other: observational study