Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Status: Completed

Conditions: Ondine Syndrome; Healthy; Amyotrophic Lateral Sclerosis

Treatments: Other: Neuropsychological tests

Study type: Observational

Funder types: Other

Identifiers

NCT03095729

ADOREPS_2017_9

Details and patient eligibility

About

The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.

Full description

Cognitive capacities are measured on healthy subject submitted to inspiratory threshold loading, patients treated by chronic mechanical ventilation due to suffering Ondine syndrome or amyotrophic lateral sclerosis. The spontaneous breathing is compared to NIV breathing or inspiratory threshold loading.

Enrollment: 65 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults and non-vulnerable adults
• Fluent in French

Exclusion criteria

For patients:

• Total ventilatory dependency
• Coexistence of an other respiratory disease
• Alcohol and /or psychotropic consumption during the last 24 hours
• One or more episodes of acute respiratory failure during the past 6 months
• Serious cognitive deficiency or presence of fronto temporal dementia
• End-stage disease
• No affiliation to social security

For healthy volunteers:

• Existing respiratory disease
• Alcohol and /or psychotropes consumption during the last 24 hours
• Tobacco smoking more than 2 pack-years
• Sleep deprivation
• Serious cognitive deficiency
• No affiliation to social security

Trial design

65 participants in 3 patient groups

Healthy

Description:

40 healthy subjects, during quiet breathing and under an inspiratory load (inspiratory threshold loading)

Treatment:

Other: Neuropsychological tests

Ondine syndrome

Description:

12 patients presenting with central hypoventilation syndrome or Ondine's curse syndrome, during spontaneous breathing and with Non Invasive Ventilation

Treatment:

Other: Neuropsychological tests

Amyotrophic Lateral Sclerosis

Description:

30 patients presenting with Amyotrophic Lateral Sclerosis during spontaneous breathing and with Non Invasive Ventilation

Treatment:

Other: Neuropsychological tests