Cognitive Control of Language (LANGUAGE)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy

Treatments: Other: Third session of fMRI; Other: Training session; Other: Second fMRI session; Other: First fMRI session

Study type: Interventional

Funder types: Other

Identifiers

NCT03124173

69HCL16_0684

Details and patient eligibility

About

The cognitive control of speech is central to human social communication. Two frontal brain regions seem to have a critical role: 1) Broca's area (BA) and 2) the mid-cingulate cortex (MCC). Current rehabilitation strategy is clearly based on therapies promoting language performance. However, there is few evidence that rehabilitation strategies based on nonlinguistic aspects of brain function may enhance recovery. Such strategies may benefit from knowledge about the primary -nonlinguistic- function of the BA-MCC network. The aim of LANGUAGE is to identify this primary function. One hypothesis is that, in non-speaking primates, this network is involved in cognitive control of voluntary vocal/orofacial production. Specifically, whereas BA may be responsible for the high-level selection of orofacial and vocal responses during learning, the face motor representation within the MCC may be responsible for performance monitoring, a process inherently required in learning. LANGUAGE aims to test this hypothesis by determining in human the anatomo-functional organization of the BA-MCC network thanks to functional magnetic resonance imaging (fMRI).

Enrollment: 23 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• being able to provide a written consent form
• having a social insurance
• have a normal vision (with or without corrections)
• Right-handed

Exclusion criteria

• Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc...).
• Subjects must be willing to be advise in case of discovery of brain abnormality.
• History of known neurological or psychiatric illness
• Pregnant or nursing women
• Persons under guardianship, curators or any other administrative or judicial measure of deprivation of rights

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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23 participants in 1 patient group

Behavioral Tasks

Other group

Description:

Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.

Treatment:

Other: First fMRI session

Other: Second fMRI session

Other: Training session

Other: Third session of fMRI