Cognitive Control of Negative Stimuli in BPD

F

Freie Universität Berlin

Status

Completed

Conditions

Borderline Personality Disorder

Treatments

Device: transcranial DC stimulation : sham
Device: transcranial DC stimulation : anodal

Study type

Interventional

Funder types

Other

Identifiers

NCT03636139
tDCS_BPD

Details and patient eligibility

About

Borderline personality disorder (BPD) is characterized by impairments in the cognitive control of negative information. These impairments in cognitive control are presumably due to blunted activity of the dorsolateral prefrontal cortex (dlPFC) along with enhanced activations of the limbic system. However, the impact of an excitatory stimulation of the dlPFC still needs to be elucidated. In the present study, we therefore assigned 50 patients with BPD and 50 healthy controls to receive either anodal or sham stimulation of the right dlPFC in a double-blind, randomized, between-subjects design.

Enrollment

100 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Borderline Personality Disorder:

Diagnosis of borderline personality disorder

Exclusion Criteria Borderline Personality Disorder:

  • Diagnosis of current or previous bipolar disorder
  • Diagnosis of current substance dependency
  • Diagnosis of current major depression
  • Diagnosis of current or previous neurological disorders (e.g., epilepsy)
  • Tattoos or scarred skin on the left shoulder or scalp (i.e. F4)

Inclusion Criteria Control Participants:

No current or previous diagnosis of a mental disorder

Exclusion Criteria Control Participants:

  • More than 2 criteria of borderline personality disorder are met
  • Diagnosis of current or previous neurological disorders (e.g., epilepsy)
  • Intake of psychotropic medication
  • Tattoos or scarred skin on the left shoulder or scalp (i.e. F4)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

100 participants in 2 patient groups

Anodal stimulation
Experimental group
Description:
transcranial DC stimulation : anodal
Treatment:
Device: transcranial DC stimulation : anodal
Sham stimulation
Sham Comparator group
Description:
transcranial DC stimulation : sham
Treatment:
Device: transcranial DC stimulation : sham

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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