Cognitive Decline in AD

The Chinese University of Hong Kong

Status

Enrolling

Conditions

Alzheimer Disease

Study type

Observational

Funder types

Other

Identifiers

NCT03946930

2018.274

Details and patient eligibility

About

There is lack of information on the risk factors of accelerated cognitive decline in older people with Alzheimer disease (AD). The extent of neurodegeneration and white matter disease has been reported to be important factors. In addition there may be biomarkers e.g. inflammatory cytokines that can contribute to cognitive decline. The impact of care arrangement and physical activity may also be important. Insulin signaling is impaired in Alzheimer disease (AD).

We therefore propose to perform a cohort study of older people with AD. This will be based on an on-going AD registry which was designed to identify genetic biomarkers for AD. Detailed neurocognitive tests and lifestyle information are available. In addition, volumetric MRI brain scans were performed in all AD subjects. The hypothesis is that MRI brain volumes, serum biomarkers, physical activity, physical functioning are independently associated with cognitive decline in older people with AD. The objective is to identify risk factors of accelerated cognitive decline so that preventive measures can be designed to delay dependency in AD.

Enrollment

500 estimated patients

Sex

All

Ages

65 to 92 years old

Volunteers

No Healthy Volunteers

Inclusion criteria