Cognitive Development After Pediatric Liver Transplantation

Shanghai Jiao Tong University

Status: Completed

Conditions: Cognitive Development After Pediatric Live Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT03778983

CDPLT

Details and patient eligibility

About

The purpose of this study is to investigate the cognitive performance after pediatric live transplantation.

Full description

During the last 20 years, survival rates after pediatric liver transplantation (Ltx) have increased steadily. Today, pediatric Ltx is a well-established treatment for a variety of liver diseases in their final stage. Even in relative indications (i.e. certain metabolic diseases), liver transplantation is a promising treatment option that actually is becoming increasingly important in clinical practice .

Importantly, childhood cognitive ability is highly predictive for educational achievement and later occupational outcomes as well as health behavior . Current research indicates that liver transplanted children are at higher risk for developing cognitive deficits compared to the age-matched normal population .

The aim of present study is to evaluate the cognitive development after pediatric liver transplantation. The investigators expect to understand of the association between cognitive deficits and certain disease-related variables, which may be contribute to optimizing clinical care of these patients.

Enrollment: 130 patients

Sex: All

Ages: 2 to 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Pediatric patients accepted Live Transplantation before 12 month, and now age between 2 and 7 years;
2. residency in China;
3. sufficient Chinese language skills;
4. at least 1 year post-Ltx;
5. no acute diseases;
6. no mental handicap.

Exclusion criteria

1. Re-transplantation
2. Patients with localized or systemic infection
3. Patients cor-morbid with auto-immune disease
4. Combined liver and kidney transplantation
5. Lack of informed consent

Trial design

130 participants in 1 patient group

Pediatric Live Transplantation Group

Description:

Children who underwent pediatric Ltx at RenJi Hospital before 12 month, and now age between 2 and 7 years;