Cognitive Fraility and Biomarkers in Older Patients

Baskent University

Status: Completed

Conditions: Orthopaedic Surgery; Cognitive Impairment; Frail Older Adults

Treatments: Behavioral: assessment Mini mental state examination; Behavioral: assessment FRAIL scale; Other: collecting cerebrospinal fluid during regional anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT07184073

KA21/124

Details and patient eligibility

About

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery.

The main questions it aims to answer is:

• Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions?
• Can these biomarkers be used as potential tools for early identification in vulnarable populations?

Full description

It is a cross sectional study

Enrollment: 129 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3 patients
• >65 age patients

Exclusion criteria

• history of psychiatric or neurological disease
• uncontrolled hypertension
• alchohol dependence
• renal failure
• active liver disease
• cancer-related or emergency surgery
• unwillingness to participate

Trial design

129 participants in 1 patient group

age 65-74

Treatment:

Other: collecting cerebrospinal fluid during regional anesthesia

Behavioral: assessment FRAIL scale

Behavioral: assessment Mini mental state examination