Cognitive Functioning in Opioid Use Disorder

New York State Psychiatric Institute

Status

Terminated

Conditions

Opioid-use Disorder

Cognitive Change

Opioid Use

Treatments

Other: CogMed

Study type

Interventional

Funder types

Other

Identifiers

NCT05001789

8185

Details and patient eligibility

About

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning. This study will also examine the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life, drug use). The training component of the study lasts 1 month, with follow up visits and 1-month and 3-months post training.

Full description

This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose (i.e. overdose that does not result in death), cognitive functioning, and the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life). Participants (n=30) with a history of at least one prior opioid OD, who are enrolled in buprenorphine treatment, will be randomized to 20 sessions of an active (n=15) or sham (n=15) working memory training. Patients will complete measures of cognitive functioning during screening, post-training, and at 1-month and 3-month follow up. Participants will also complete the measures of decision making, psychosocial functioning and drug use at baseline, post-training, and follow up.

Enrollment

13 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Meets DSM-5 criteria for moderate-severe Opioid Use Disorder (OUD) in the past 6 months
Enrolled in a suboxone (buprenorphine/naloxone) program; willing to provide consent for research team to contact treatment provider
History of at least 1 prior opioid overdose
Recent history of illicit opioid use
In good physical health
Access to a smartphone, tablet, or computer

Exclusion criteria

Evidence of a co-occurring, untreated psychiatric condition that would make participation risky or difficulty
Lack of access to a home computer, smartphone, or tablet
Unable to speak, read and/or communicate in English