Cognitive Impairment and Imaging Correlates in End Stage Renal Disease

University of Kansas

Status: Completed

Conditions: End Stage Renal Disease

Treatments: Other: No kidney transplant; Procedure: Kidney Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT01883349

13566

Details and patient eligibility

About

This is an observational cohort to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

Full description

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.

Enrollment: 120 patients

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pre-transplant ESRD patients who are listed for renal transplantation
• Able to sign pre-transplant consent on their own will
• Have english as their native language

Exclusion criteria

• Current use of antipsychotics or anti-epileptics
• Inability to read or write which will limit their ability to perform the cognitive tests
• Claustrophobia or inability to get MRI for other reasons
• Unable to sign consent

Trial design

120 participants in 2 patient groups

ESRD patients

Description:

ESRD patients awaiting renal transplantation

Treatment:

Procedure: Kidney Transplant

Control Arm

Description:

Subjects without kidney disease. No intervention with control group.

Treatment:

Other: No kidney transplant