COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old (COGITO)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Cognitive Impairment; Memory Impairment; HIV/AIDS

Treatments: Other: assessment of cognitive impairment

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03268109

AMR_2017_3

Details and patient eligibility

About

Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

Enrollment: 281 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Personal or familial cognitive complaints
• Individual aged ≥ 65 years old and < 81 years old
• Instrumental activities of daily living (IADL) score between 3-4
• French speaking individual
• Informed consent signed For PLHIV
• HIV infection
• Undetectable HIV viral load ≥ 1 year
• Current cluster of differentiation (CD4) cell count > 100/mm3 For controls
• negative HIV serology ≤ 6 months

Exclusion criteria

• Opportunistic infection < 5 years
• Contraindications to MRI

Trial design

281 participants in 2 patient groups

people living with HIV

Description:

subjects infected with HIV and with cognitive complaints

Treatment:

Other: assessment of cognitive impairment

control subjects

Description:

subjects not infected with HIV and with cognitive complaints

Treatment:

Other: assessment of cognitive impairment