Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly (CIRCLE)

Zhejiang University

Status: Enrolling

Conditions: Retinopathy; Cerebral Small Vessel Diseases; Cognitive Dysfunction

Treatments: Other: multimodal magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT03542734

CIRCLE-CHINA

Details and patient eligibility

About

The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage). The patients will receive neuropsychological testing, retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD and cognitive deficits.

Full description

Cerebral small vessel disease (SVD) is commonly detected in elderly individuals, and patients with stroke or neurodegenerative disease. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. Previous studies indicated that SVD was associated with an increased risk of stroke and stroke recurrence, cognitive deficits, physical disabilities, and mortality. However the pathogenesis of SVD is largely unknown. Little is known about how SVD lesions contribute to neurological or cognitive symptoms, and the association with risk factors. Recent data sugessted concomitant SVDs and retinopathy is associated with a profile of vascular cognitive impairment. In this study, the investigators try to explore the new pathological mechanism of SVD, the new predictors for SVD progression, and the association with cognitive Impairment, based on digital retinal images and brain multimodal imaging technique.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult (≥40y; no upper limit)
• Free of known dementia or stroke (both cerebral infarction and hemorrhage)

Exclusion criteria

• Any MRI contraindications
• Serious head injury (resulting to loss of consciousness) or received intracranial surgery
• Suffering from cancer

Trial design

1,000 participants in 2 patient groups

Individuals with SVDs

Description:

Individuals with at least one following imaging finding: recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, or brain atrophy on baseline brain MRI.

Treatment:

Other: multimodal magnetic resonance imaging

Individuals without SVDs

Description:

Individuals without any following imaging finding: recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, or brain atrophy on baseline brain MRI.

Treatment:

Other: multimodal magnetic resonance imaging