Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Leila DJABELKHIR

Status: Completed

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Computerized Cognitive Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03195803

LUS2WMH

Details and patient eligibility

About

This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

Full description

White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Enrollment: 51 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Mild Cognitive Impairment
• With and without white matter hyperintensities
• MRI available or accept to perform one
• No engagement in other cognitive intervention program

Exclusion criteria

• Psychiatric and neurological disorders
• History of alcohol or other substance abuse
• Sensory and/or motor deficit affecting the use of a tablet

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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51 participants in 2 patient groups

MCI with WMH

Experimental group

Description:

Computerized Cognitive Stimulation was administered to this group, twice a week.

Treatment:

Behavioral: Computerized Cognitive Stimulation

MCI without WMH

Active Comparator group

Description:

Computerized Cognitive Stimulation was administered to this group, twice a week.

Treatment:

Behavioral: Computerized Cognitive Stimulation