Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes. (COGMOTION)

The Hong Kong Polytechnic University

Status: Enrolling

Conditions: Stroke

Treatments: Behavioral: Single-task training; Behavioral: Upper limb strengthening exercise; Behavioral: Dual-task training

Study type: Interventional

Funder types: Other

Identifiers

NCT06362512

Marco_PANG_2024

Details and patient eligibility

About

The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.

Full description

The prevalence rate of stroke increased by 106.0% (93.7-118.8) from 1990 to 2019 in China, and stroke burden is still severe. Community ambulation is an important factor that influences health-related quality of life after a stroke.In daily living, effective community ambulation requires the ability to maintain balance and walking function while engaging in other tasks that demand attentional resources simultaneously (i.e., dual-tasking). Increasing evidence has shown that stroke patients have more problems with dual-task balance and walking function than their age-matched able-bodied peers. stroke individuals were found to have more reduction in both the walking speed and cognitive recall than control group during walking with remembering a shopping list. Hence, since stroke victims must reintegrate into community, this kind of cognitive-motor interference needs to be thoroughly studied.

Enrollment: 84 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Clinical diagnosis of stroke, Stroke onset of more than 6 months Aged 50 or more Capable of following verbal instructions Having a Montreal Cognitive Assessment score≥22, Able to walk for 1 minute without physical assistance Not receiving any formal rehabilitation training Having a Fugl-Meyer Ankle dorsiflexion-standing position score≥1

Exclusion Criteria

Contraindications to exercise (e.g., unstable angina) Contraindications to MRI (e.g., pacemaker) Color blindness Neurological disorders Gait-precluding pain Comorbidity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 3 patient groups

dual-task group

Experimental group

Description:

patients receive three dual motor-cognitive exercise training per week for six weeks.

Treatment:

Behavioral: Dual-task training

single-task group

Active Comparator group

Description:

Patients receive three separate cognitive and mobility exercises per week for six weeks.

Treatment:

Behavioral: Single-task training

control group

Active Comparator group

Description:

Patients receive three upper limb muscle strengthening exercise with muscle stretching per week for six weeks.

Treatment:

Behavioral: Upper limb strengthening exercise