Cognitive Recovery After Post Stroke Delirium (RECOVER)

University Hospital Tuebingen

Status: Enrolling

Conditions: Post Stroke Delirium; Cognitive Functioning After Stroke

Treatments: Diagnostic Test: Multimodal MRI; Diagnostic Test: Mulit-componant neuropsychological assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT06680336

AKF_1004-0-0

Details and patient eligibility

About

RECOVER is a Proof-of-Concept study on cognitive functioning following a longitudinal design with three measurements (during the acute- and post-acute phases of a stroke and a 3-month follow-up) and two equally-sized stroke patient groups: a post-stroke delirium(PSD), and a non-PSD group (control group). Cognitive functioning will be assessed using a multi-component neuropsychological assessment and tasked-based functional MRI (introducing a modified working memory task).

Enrollment: 40 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 60 years
• Ischemic stroke: Stroke Onset ≤ 96h, hospital admission ≤ 48h
• NIHSS ≥ 1
• Informed consent by patient or legal guardian

Exclusion criteria

• Aphasia
• Pre-existing conditions such as Dementia, psychiatric disorders (e.g., Depression, Schizophrenia)
• MRI contraindication such as certain metal implants
• Reduced consciousness, defined as Glasgow Coma Scale (GCS) ≤ 8
• Delirium onset before study enrollment

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Post-stroke Delirium

Other group

Description:

Assessment of cognitive functioning using a multi-component neuropsychological assessment and tasked-based functional MRI (introducing a modified working memory task) at three time points S1, S2, S3.

Treatment:

Diagnostic Test: Mulit-componant neuropsychological assessment

Diagnostic Test: Multimodal MRI

Non-post-stroke Delirium

Other group

Description:

Assessment of cognitive functioning using a multi-component neuropsychological assessment and tasked-based functional MRI (introducing a modified working memory task) at three time points S1, S2, S3.

Treatment:

Diagnostic Test: Mulit-componant neuropsychological assessment

Diagnostic Test: Multimodal MRI