Cognitive Rehab for Parkinson's

VA Office of Research and Development

Status

Completed

Conditions

Mild Cognitive Impairment

Parkinson's Disease

Treatments

Behavioral: active control cognitive training

Behavioral: cognitive training

Behavioral: memory strategy training

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT03836963

RX003015 (Other Grant/Funding Number)

N3015-P

Details and patient eligibility

About

This study will examine the feasibility of an at-home cognitive training program that incorporates both memory training and online computerized cognitive training (CCT) software. Data will also be collected to determine if this program improves thinking and memory as well as everyday function. The hypothesis is that memory and cognitive training combined , compared to memory training alone or will lead to greater improvements in cognitive performance and daily function.

Full description

The objective of this study is to examine feasibility of an at-home cognitive rehabilitation program that incorporates both prospective implementation intentions strategies (PRIIS) and an existing web-based executive function (EF) computerized cognitive training (CCT) software for Veterans with Parkinson's disease (PD) and to collect pilot data to determine the impact of this program on cognition and everyday function. The central hypothesis is that CCT+PRIIS, compared to CCT alone and an active control group, will lead to greater improvements in cognitive performance and daily function. This innovative study uses a set of on-line training games that target aspects of EF susceptible in PD and trains the transfer of cognitive benefits to everyday function, using PRIIS, for Veterans with PD and mild cognitive impairment in executive function. Additionally, training is conducted at home allowing for convenience and flexibility for participants.

Enrollment

6 patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Veterans who seek services at Hines VA Hospital
Diagnosis of PD as determined by the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria
Meet criteria for having mild cognitive impairment
Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT
50 years or older
Speak and read English

Exclusion criteria

Dementia
Failure to demonstrate decision making capacity
Cholinesterase inhibitor medication
History of deep brain stimulation surgery
Severe depression
Severe anxiety
Severe apathy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

6 participants in 3 patient groups

cognitive and memory strategy training

Experimental group

Description:

The cognitive training will include 4 sessions/week for 8 weeks. Each session will take 30min. Total hours of training is 16 hours. For memory strategy training, strategies will be performed daily; this will take only a few minutes a day to accomplish.

Treatment:

Behavioral: memory strategy training

Behavioral: cognitive training

cognitive and memory strategy control training

Active Comparator group

Description:

The cognitive training will include 4 sessions/week for 8 weeks. Each session will take 30min. Total hours of training is 16 hours. For the active control of memory strategy training, strategies will be performed daily; this will take only a few minutes a day to accomplish.

Treatment:

Behavioral: memory strategy training

Behavioral: cognitive training

active control for cognitive and memory strategy training

Active Comparator group

Description:

Treatment:

Behavioral: memory strategy training

Behavioral: active control cognitive training

Trial documents