Cognitive Rehabilitation in Patients With Depression

Lovisenberg Diakonale Hospital

Status

Unknown

Conditions

Depression

Treatments

Behavioral: Computerized Cognitive Training

Behavioral: Goal Management Training

Study type

Interventional

Funder types

Other

Identifiers

NCT03338413

2017/666

Details and patient eligibility

About

Depression is a highly prevalent and debilitating mental disorder, ranked one of the leading causes of disability worldwide. Several studies have identified neuropsychological deficits in populations of depressed patients affecting domains including attention, memory and executive functioning. These deficits often persist even in patients whose depressive symptoms have remitted. Cognitive impairment in depression represent a core feature of depression, and a valuable target for intervention. Identification of methods that would lead to amelioration would be of great clinical interest, and cognitive rehabilitation (CR) could be a potential way of achieving this. To date few studies on cognitive rehabilitation in depression has been conducted, but the preliminary results are promising. Still the demonstration of long-term effects and evidence relating to improved daily life executive functioning (i.e., generalization) is lacking. In the present study different group-based cognitive rehabilitation interventions will be compared. The aim of the study is to investigate if a group-based "brain training" intervention can improve executive function in patients with active and remitted depression. Efficacy will be assessed immediately after intervention, but also six months after the intervention.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Completed treatment for mild or moderate MDD
Evidence of executive dysfunction in everyday life determined by (a) a structured interview or (b) a self-report Behavior Rating Inventory of Executive Function (BRIEF) T-score < 55.

Exclusion criteria

Cognitive, sensory, physical, or language impairment affecting the capacity to complete the training program.
Premorbid neurological disease or insult and/or comorbid neurological disorder.
Reported ongoing alcohol or substance abuse.
Psychotic disorders.
Actively suicidal.
Personality disorder sever enough to interfere with the protocol.
Not fluent in Norwegian language.