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Cognitive Remediation in Schizophrenia

U

University of Dublin, Trinity College

Status

Unknown

Conditions

Psychosis
Schizophrenia

Treatments

Other: Cognitive Remediation Therapy
Other: Placebo comparator

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses.

Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.

Full description

The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on

  1. Neuropsychological performance
  2. Brain Structure using voxel-based morphometry (VBM)
  3. Brain function using functional MRI (fMRI)
  4. Social and occupational functioning

The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Schizophrenia
  • History of Psychosis
  • Subjective difficulties with memory or concentration
  • Aged 18-60 Years

Exclusion criteria

  • History of head injury resulting in loss of consciousness
  • Substance misuse in the last 3 months

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

80 participants in 2 patient groups, including a placebo group

Cognitive Remediation Therapy
Experimental group
Description:
Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week. They will meet a therapist once per week to discuss any difficulties, help motivation.
Treatment:
Other: Cognitive Remediation Therapy
Placebo Comparator
Placebo Comparator group
Description:
Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training.
Treatment:
Other: Placebo comparator

Trial contacts and locations

1

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Central trial contact

Rachael Dillon, Bsc; April H Hargreaves, PhD

Data sourced from clinicaltrials.gov

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