Cognitive Status After Removal of Skull Base Meningioma

The Ohio State University

Status: Enrolling

Conditions: Cognitive Impairment; Meningioma; Cognitive Decline; Temporal Meningioma; Post-Surgical Cognition; Skull Base Meningioma; Frontal Meningioma

Treatments: Other: Long-term Cognitive testing

Study type: Observational

Funder types: Other

Identifiers

NCT04635657

2019H0340

Details and patient eligibility

About

The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.

Full description

This study will look at patients who are undergoing resection of a skull based meningioma, located in the frontal or temporal lobe, via craniotomy or via endoscopic endonasal approach. The study will compare cognitive function at baseline, at six weeks postoperatively and at one year postoperatively. The cognitive testing being done at baseline will be a clinical care set of assessments done by the speech language pathology team and will include the RBANS tests, the MoCA, PROMIS-29, and NeuroQOL-Cognitive Functions.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject has a meningioma associated with the frontal or temporal lobes
• Subject is scheduled to undergo open craniotomy or Endoscopic Endonasal surgery
• Subject is 18 years of age or older
• The subject must in the investigator's opinion, be psychosocially, mentally, and physically able to fully comply with this protocol including the required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent
• Previous surgery will not exclude the patient as a new baseline cognitive evaluation will occur.

Exclusion criteria

• Patient is a prisoner
• Patient is 90 years of age or older
• Pregnant women
• Previous radiation to the brain

Trial design

50 participants in 1 patient group

Meningioma Group

Description:

This group will include all patients in the study, regardless of location (frontal or temporal lobe) or surgical approach (endoscopic endonasal or craniotomy). Fifty patients will be included in the cohort

Treatment:

Other: Long-term Cognitive testing