Cognitive Training for Nicotine Dependence

University of Pennsylvania

Status: Completed

Conditions: Tobacco Use Disorder; Nicotine Addiction

Treatments: Behavioral: Control training; Behavioral: Cognitive Training

Study type: Interventional

Funder types: Other

Identifiers

NCT01252966

812429

Details and patient eligibility

About

This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.

All participants received 8 weeks of standard nicotine patch therapy, smoking cessation counseling, and were randomized to 1 of 2 different training programs: cognitive training vs. control training.

Enrollment: 213 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion:

1. Healthy male and female treatment-seeking smokers who are between 18 and 65 years of age and self-report smoking at least 5 cigarettes (menthol and/or non-menthol) per day for at least the last 6 months
2. Plan to live in the area for at least the next 8 months
3. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form
4. Able to communicate fluently in English (speaking, writing, and reading)
5. Have uninterrupted access to a home computer with sound capabilities, keyboard, mouse, and active Internet connection
6. Provide a Carbon Monoxide (CO) breath test reading greater than or equal to 8 parts per million (ppm) at Intake Visit

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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213 participants in 2 patient groups, including a placebo group

Cognitive Training

Experimental group

Description:

Participants in this arm received computerized cognitive training in addition to nicotine patch and smoking cessation counseling.

Treatment:

Behavioral: Cognitive Training

Control Training

Placebo Comparator group

Description:

Participants in this arm received computerized control training in addition to nicotine patch and smoking cessation counseling

Treatment:

Behavioral: Control training