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Cognitive Training for Patients With Eating Disorders (TCRTRCT)

N

Norwegian University of Science and Technology

Status

Active, not recruiting

Conditions

Binge-Eating Disorder
Bulimia Nervosa
Anorexia Nervosa
Feeding and Eating Disorders

Treatments

Behavioral: Cognitive Remediation Therapy
Other: Treatment as usual

Study type

Interventional

Funder types

Other

Identifiers

NCT03808467
2018/1182

Details and patient eligibility

About

Eating disorders are severe mental illnesses, mainly affecting adolescent- and young adult women. The prognoses for eating disorders are relatively poor, and a large part of patients with these illnesses do not benefit from available conventional therapies. After decades of research into the causes of eating disorders, there is now compelling evidence for specific neuropsychological difficulties in patients affected by eating disorders. These neuropsychological difficulties are characterized by cognitive and behavioral rigidity (poor set-shifting abilities), as well as difficulties related to central coherence, planning and impulse control. Surprisingly, few therapies specifically target these difficulties, and they are rarely incorporated into treatment. Cognitive Remediation Therapy has shown promising results as an adjunctive therapeutic intervention for patients with anorexia Nervosa. The primary aim of this randomized controlled trial is thus to investigate the effect of Cognitive Remediation Therapy on neuropsychological function, symptoms of eating disorders and general mental health, quality of life and motor activity in women with both eating disorders (transdiagnostic) and these specific cognitive difficulties.

Enrollment

100 estimated patients

Sex

Female

Ages

16 to 36 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Being in in-patient-, day- or out-patient treatment for an eating disorder (anorexia nervosa, bulimia nervosa, binge eating disorder or OSFED)

  • Displaying cognitive difficulties (score ≤ -1 standard deviation) on:

    1. the Inhibit, Shift, Plan/ Organize and/ or Global Executive Composite indexes of the self-report measure the BRIEF-A (reversed)
    2. the Total errors, Perseverative Responses, Perseverative Errors and/ or Learning to learn from the Wisconsin Card Sorting Test (WCST) and/ or on the Rey Complex Figure Test (RCFT) Copy condition or Q-score and/ or on condition 3 and 4 on the Color-word Interference Test from (D-KEFS)
  • Being able to understand and speak Norwegian

  • Be willing to provide written informed consent

  • Accepting random allocation to the two arms of the study

Exclusion criteria

  • A history of congenital or acquired brain injury (except concussions)
  • Active substance abuse
  • Psychosis
  • Intelligence quotient (IQ) less than 70

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

100 participants in 2 patient groups

CRT + TAU
Experimental group
Description:
Cognitive Remediation Therapy + Treatment As Usual
Treatment:
Other: Treatment as usual
Behavioral: Cognitive Remediation Therapy
TAU only
Other group
Description:
Treatment As Usual
Treatment:
Other: Treatment as usual

Trial contacts and locations

3

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Central trial contact

Siri Weider, PhD; Tora Thorsrud, Cand Psychol

Data sourced from clinicaltrials.gov

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