Cohort Construction for Preterm Infants With Growth Retardation and Its Influencing Factors

Peking University

Status: Unknown

Conditions: Problem With Growth of an Infant

Treatments: Combination Product: Developmental assessment

Study type: Observational

Funder types: Other

Identifiers

NCT04817878

bysy2020-423-01

Details and patient eligibility

About

In this cohort, prospective clinical cohort study was used to establish a follow-up cohort of preterm infants with different gestational ages. The regular monitoring indexes of physical development and neuropsychological development of preterm infants from birth to 3 years after birth were collected. The influencing factors of preterm infants' development at different stages were recorded, and the high-risk factors leading to different stages of preterm infants' growth retardation were analyzed.

Full description

Preterm infants are at high risk of stunting due to premature birth, insufficient intrauterine nutrient reserves, burden of various diseases after birth, and persistent nutrient liabilities. The growth retardation of premature infants at different developmental stages has an important impact on both short-term survival and long-term health. The growth and development data of premature infants during hospitalization and after discharge are very limited in foreign countries. Domestic researches on growth retardation of preterm infants only involve retrospective cross-sectional studies during hospitalization, and lack of prospective follow-up study data on growth and development data of premature infants during hospitalization and after discharge.

In this cohort, prospective clinical cohort study was used to establish a follow-up cohort of preterm infants with different gestational ages. The regular monitoring indexes of physical development and neuropsychological development of preterm infants from birth to 3 years after birth were collected. The influencing factors of preterm infants' development at different stages were recorded, and the high-risk factors leading to different stages of preterm infants' growth retardation were analyzed. In order to provide a strong scientific basis for the development evaluation and intervention of premature infants in China, a systematic and scientific clinical cohort study method was explored to improve the overall medical quality and medical level of the Department and further promote the development of the discipline.

Enrollment: 2,400 estimated patients

Sex: All

Ages: 24 to 37 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All preterm infants born less than 37 weeks during the study period

Exclusion criteria

• Congenital malformations or genetic diseases Various surgical treatments during the newborn period Interrupted treatment or discharged automatically

Trial design

2,400 participants in 3 patient groups

Late preterm infant group

Description:

Gestational age 33 weeks-36 weeks

Treatment:

Combination Product: Developmental assessment

Very premature infant group

Description:

Gestational age 28 weeks-32 weeks

Treatment:

Combination Product: Developmental assessment

Super preterm infant group

Description:

Gestational age less than 28 weeks

Treatment:

Combination Product: Developmental assessment