Cohort Study on the Effects of Aging in Acquired Brain Injury Patients (BRAINReADAPT)

University Medical Center Groningen (UMCG)

Status: Invitation-only

Conditions: Cerebrovascular Accident; Subarachnoid Hemorrhage; Traumatic Brain Injury; Acquired Brain Injury

Study type: Observational

Funder types: Other

Identifiers

NCT05499806

NL79072.042.21

Details and patient eligibility

About

A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years. A group of 700 patients and a group of 100 healthy volunteers will be participating.

Full description

In the Netherlands an estimated 650.000 people live with the daily consequences of an Acquired Brain Injury (ABI). A substantial amount of these patients acquired their brain injury (traumatic brain injury, subarachnoid hemorrhage or cerebrovascular accident) at a relatively young age: between 18 and 50 years old. The chain-of-care for ABI aims for recovery in the subacute phase, usually within a period of one year after injury. After an adaptation period, the patients reach a new balance, with stabilization of complaints and reintegration, sometimes with the necessity of modifications. The group of patients who acquired a brain injury at a young age, have to face the effects of aging like decreased cognitive functions, which can cause the participation level to drop. This is called the ABI-effect in the current study. At this moment, insufficient information is available about the functioning of people who suffered ABI multiple years ago and have established a new balance, and now make the transition to an older phase of live.

Primary objective:

Explore the prevalence of the ABI-effect, by mapping the participation level.

Secondary objective:

Substantiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls.

Tertiary objective:

Gain insight in the need of care for patients, to enhance regular care after ABI.

Enrollment: 800 estimated patients

Sex: All

Ages: 50 to 67 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Current age range between 50-67 years [Rationale: having an age that enables the patient to experience the effects of aging with a low risk of neurodegenerative disease]
• Able to complete questionnaires independently

Additionally, patients must also meet the following criteria:

• Age of acquiring the ABI ≧ 25 years [Rationale: the brain is supposed to be fully developed at a maximum capacity
• ABI must be ≧ 5 years ago] [Rationale :time period regarded sufficient to have achieved a stable level of cognitive functioning and participation after an ABI]
• ABI diagnosis at hospital admission with abnormalities at the brain-CT or MRI
• Independent regarding Activities of Daily Living
• Not living in a long-term care facility

Exclusion criteria

• Psychiatric disease (for which participant is currently treated)
• Accompanying disease with reduced life expectancy
• Neurological disease (including recurrent ABI for patients)
• Language barriers prohibiting and completion of Dutch questionnaires
• Alcohol or drug abuse
• Suspected neurodegenerative disease

Trial design

800 participants in 2 patient groups

Acquired Brain Injury Patients

Description:

Questionnaire and, if the requirements are met, a neuropsychological assessment.

Healthy volunteers

Description:

Questionnaire and, if the requirements are met, a neuropsychological assessment.