Cohort Study to Determine the Antitumor Activity of New CAR-macrophages in Breast Cancer Patients' Derived Organoids (CARMA)

Centre Oscar Lambret

Status: Unknown

Conditions: Breast Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT05007379

CARMA-2101

Details and patient eligibility

About

Cell-based immune therapy using modified macrophages is a promising therapeutic approach in breast cancer. The objective of this cohort study is to collect tumor samples to develop patients' derived organoids to test the antitumor activity of newly developed CAR-macrophages. Other biological samples will be collected such as blood to analyze the host inflammatory status.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female aged 18 years or more
• Histologically confirmed breast cancer at any stage
• Requiring surgery or tumor biopsy as standard of care
• Any or no systemic treatment
• Signed informaed consent
• Health insurance coverage

Exclusion criteria

• Opposed to biospecimen collection