Cold Saline Irrigation Before Endobronchial Biopsy

TriHealth

Status: Invitation-only

Conditions: Lung Diseases

Treatments: Other: Flush

Study type: Interventional

Funder types: Other

Identifiers

NCT06373224

23-037

Details and patient eligibility

About

Patients undergoing an endobronchial ultrasound and biopsy can experience bleeding during the biopsy. These biopsies are read in real time by pathologists who travel to the endoscopy unit during the procedure. Often, when this happens, the blood contaminates the pathology slides making the slide unreadable. This then requires more biopsies to be performed, thus prolonging the procedure, and increasing anesthesia time. One innovative way to reduce bleeding may be to irrigate the bronchial wall with cold saline, where the biopsy is to be taken, immediately before biopsy, thus causing vasoconstriction and possibly resulting in less blood contamination on the biopsy slides. The current study will evaluate this prophylactic irrigation with saline to control bleeding, thus resulting in a quicker diagnostic result of the biopsies.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing an endobronchial ultrasound and biopsy at Bethesda North Hospital

Exclusion criteria

• Under 18 years old
• Does not speak English
• Unable to consent to involvement in the research study
• Is pregnant
• Has a bleeding disorder/diagnosis
• Currently taking anticoagulant medications and not stopped for procedure
• Documented low platelets (<100,000)
• Had a biopsy taken immediately prior to the endobronchial ultrasound

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Flush Group

Experimental group

Description:

After identifying the lymph node or lesion to be biopsied on ultrasound, using the endobronchial ultrasound scope, two 60mL syringes of cold saline will be inserted, through the biopsy channel of the endobronchial ultrasound scope, directly onto the bronchial wall where the biopsies are to be performed. The saline will then be sucked out of the airway using the endobronchial ultrasound scope.

Treatment:

Other: Flush

Standard Care Group

No Intervention group

Description:

No irrigation before the biopsy