Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 0% N2O; Drug: 40% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000250

NIDA-08391-2

R01-08391-2

R01DA008391 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Enrollment: 12 patients

Sex: All

Ages: 21 to 32 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 2 patient groups

Lukewarm water

Active Comparator group

Description:

Subjects will immerse forearm in lukewarm water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial

Treatment:

Drug: 40% N2O

Drug: 0% N2O

Ice cold water

Active Comparator group

Description:

Subjects will immerse forearm in ice cold water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial

Treatment:

Drug: 40% N2O

Drug: 0% N2O