Collagen Alterations in Patients With Abdominal Wall Hernias

Bispebjerg Hospital

Status: Completed

Conditions: Hernia, Abdominal

Treatments: Other: Collagen turnover

Study type: Observational

Funder types: Other

Identifiers

NCT02734563

H.A-2009-045

Details and patient eligibility

About

The aim of this study was to evaluate collagen turnover in patients with multiple hernias

Full description

Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured

Enrollment: 174 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with a history of three hernia repairs (multiple hernia group)
• patients without any history or presence of hernias (control group)

Exclusion criteria

• connective tissue disorder (Ehlers-Danloss/Marfan)
• presence of hernia upon clinical examination (control group)

Trial design

174 participants in 2 patient groups

Multiple hernia group

Description:

Males undergoing at least three repairs of abdominal wall hernias at three different anatomic locations. Collagen turnover is analysed.

Treatment:

Other: Collagen turnover

Control group

Description:

Males without any history or presence of hernias

Treatment:

Other: Collagen turnover