Collagen Cross-linking in Infectious Keratitis Trial

Chulalongkorn University

Status and phase: Completed; Phase 2

Conditions: Fungal Keratitis; Bacterial Keratitis; Infectious Keratitis

Treatments: Procedure: Collagen cross-linking

Study type: Interventional

Funder types: Other

Identifiers

NCT01831206

438/55

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.

Enrollment: 30 patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Evidence of corneal ulcer grade II or III (bacteria or fungal, or presumed bacterial or fungal)
• Age more than 6 year
• Patients can understand and can follow the study protocol

Exclusion criteria

• Pregnancy by history or urine test
• Evidence of herpetic keratitis
• Evidence of corneal perforation
• Evidence of autoimmune disease
• Known allergy to study medication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Collagen cross-linking

Experimental group

Description:

Collagen cross-linking with standard treatment

Treatment:

Procedure: Collagen cross-linking

standard treatment

No Intervention group

Description:

Standard treatment alone