Collagen Protein Versus Placebo on Muscle Recovery

University of Central Florida

Status: Not yet enrolling

Conditions: Pain Scale; Anthropometrics: Height and Weight; Myotonography of the Calf Musculature and Achilles Tendon; Achilles Tendon Length and Thickness; Pain Pressure Threshold of the Calf; Isometric Standing and Seated Plantarflexion; Calf Muscle Thickness; Dietary Analysis; Endurance Calf Test

Treatments: Dietary Supplement: Collagen; Dietary Supplement: Maltodextrin

Study type: Interventional

Funder types: Other

Identifiers

NCT06465407

UCFlorida1

Details and patient eligibility

About

This study is focused on exploring the gap in the literature by comparing the effects of collagen protein versus placebo supplementation on the musculotendinous unit following muscle damaging protocol. Thus, the purpose of this study is to identify and compare the effect of collagen protein versus placebo supplementation on indirect markers of musculotendinous unit recovery following eccentric calf exercises.

Full description

Various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, will consume a daily dose of two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan) or placebo (30 g of pure maltodextrin with no amino acids) mixed in 300 ml of orange Gatorade zero.

Gatorade zero, maltodextrin, and collagen is going to be stored in the locked cabinet in the lab. Research team will mix the supplement (placebo or maltodextrin) with Gatorade zero in a non-clear bottle and will administer it to the participants on-site.

Enrollment: 36 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males between the ages of 18-30 years old
• Determined to be healthy by PAR-Q+ and the HHQ

Exclusion criteria

• Untrained (no resistance training in the past 3 months)
• Any response of "yes" on the PAR-Q+; exclusion criteria noted on the HHQ
• Allergy to bovine collagen or maltodextrin

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

---

36 participants in 3 patient groups, including a placebo group

Collagen

Experimental group

Description:

Collagen supplementation group will have 12 participants. They will perform various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, they will consume a daily dose of two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan).

Treatment:

Dietary Supplement: Collagen

Placebo

Placebo Comparator group

Description:

Placebo supplementation group will have 12 participants. They will perform various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, they will consume a daily dose of placebo (two 30 g of pure maltodextrin with no amino acids) mixed in 300 ml of orange Gatorade zero.

Treatment:

Dietary Supplement: Maltodextrin

Control

No Intervention group

Description:

Control group (n=12) will receive no supplement. Control group participants will do all the assessments that the intervention participants are performing, except for the standardized exercise routine focused on the eccentric movements. Randomization will be performed via www.randomizer.org website.