Collect of Cord Blood From Subjects at Risk for Sickle Cell Disease, for the Purpose of Laboratory Research (DREPACORD)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Sickle Cell Disease

Study type: Observational

Funder types: Other

Identifiers

NCT03876821

C18-31

Details and patient eligibility

About

The study consists in collecting umbilical cord blood cells from newborns at risk of sickle cell disease, to perform laboratory experiments aiming to characterize the cells with HbS/HbS mutation, to develop methods to prepare, to gene-modify and to preserve these cells.

Full description

Pregnant individuals carrying at least one HbS allele will be included in the study to collect the umbilical cord blood of the child at birth. Collected cells will be used anonymously for genetic and bioexperimental laboratory research, aiming to develop autologous gene therapy for sickle cell disease.

Enrollment: 44 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women, giving birth at CHSF and consenting to the collect and study of placental blood after delivery
• Age 18 to 45 years
• Biological testing of the participant includes hemoglobin electrophoresis and shows at least one HbS allele

Exclusion criteria

• Lack of written consent
• Minors (not 18 years old) or under guardianship
• Diseases : HIV, Hepatitis B, Hepatitis C or HTLV (Human T Leukemia Virus).